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ORIGINAL ARTICLE
Year : 2019  |  Volume : 13  |  Issue : 2  |  Page : 60-64

Comparison of serum dehydroepiandrosterone sulfate, testosterone, and dihydrotestosterone levels in males with various degrees of acne vulgaris severity


Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia

Correspondence Address:
Dr. Arif Widiatmoko
Department/SMF of Dermatology and Venereology, Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar General Hospital, Malang, East Java
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/TJD.TJD_12_19

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Objective: This study compared the levels of dehydroepiandrosterone (DHEA) sulfate, testosterone, and dihydrotestosterone (DHT) in the serum of men with various degrees of severity grading of acne vulgaris. Methods: We conducted a cross-sectional analytic observational study and used the Combined Acne Severity Classification. Serum DHEA sulfate (DHEAS), testosterone, and DHT levels were measured by enzyme-linked immunosorbent assay. We recruited 63 males with acne vulgaris. Results: For mild, moderate, or severe acne, the mean serum level of DHEAS was 90.92, 153.54, and 166.67 ng/ml (P = 0.000); testosterone was 6.66, 8.11, and 8.97 ng/ml (P = 0.445); and DHT was 87.33, 111.72, and 124.71 (P = 0.01), respectively. Post hoc analysis showed significant differences for DHEAS and DHT serum levels. There were significant differences for DHEAS and DHT serum levels. Conclusion: There was no significant difference in serum testosterone levels between groups, although there was an increase in concentration by acne vulgaris severity.


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