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ORIGINAL ARTICLE
Year : 2019  |  Volume : 13  |  Issue : 4  |  Page : 131-134

Thiol/disulfide homeostasis in patients with telogen effluvium: is oxidative stress important in the pathogenesis of telogen effluvium?


1 Department of Medical Microbiology, Hitit University Erol Olcok Education and Research Hospital, Çorum, Turkey
2 Department of Medical Biochemistry, Hitit University Erol Olcok Education and Research Hospital, Çorum, Turkey
3 Department of Dermatology, Hitit University Faculty of Medicine, Çorum, Turkey
4 Department of Plastic and Reconstructive Surgery, Hitit University Faculty of Medicine, Çorum, Turkey
5 Department of Urology, Hitit University Erol Olcok Education and Research Hospital, Çorum, Turkey
6 Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey

Correspondence Address:
Dr. Unsal Savci
Department of Medical Microbiology, Hitit University Erol Olcok Education and Research Hospital, Çorum
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/TJD.TJD_26_19

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Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, <0.001, 0.013, 0.026, and < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.


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