|Year : 2020 | Volume
| Issue : 1 | Page : 25-27
A psoralen and ultraviolet A-aggravated dermatosis: Grover's disease
Emin Ozlu1, Ayse Serap Karadag2, Tugba Kevser Uzuncakmak2, Seyma Ozkanli3, Aysegul Erdem3, Necmettin Akdeniz2
1 Department of Dermatology, Duzce University School of Medicine, Duzce, Turkey
2 Department of Dermatology, Istanbul Medeniyet University, Istanbul, Turkey
3 Department of Pathology, Istanbul Medeniyet University, Istanbul, Turkey
|Date of Submission||20-Dec-2019|
|Date of Decision||30-Dec-2019|
|Date of Acceptance||01-Jan-2020|
|Date of Web Publication||25-Feb-2020|
Dr. Emin Ozlu
Department of Dermatology, Duzce University Faculty of Medicine, Duzce
Source of Support: None, Conflict of Interest: None
Grover's disease (GD) is an acquired dermatosis called transient acantholytic dermatosis. The exact cause is unknown, but the factors blamed for the etiology include ultraviolet (UV), sweating, temperature rise, radiation, medications, and malignancies. Topical corticosteroids, topical retinoids, and topical calcipotriol are usually sufficient for treatment, and systemic retinoids, systemic steroids, phototherapy, and methotrexate are rarely used. The current report describes the case of GD in a female patient, which was aggravated by the psoralen and UVA phototherapy.
Keywords: Grover's disease, phototherapy, treatment
|How to cite this article:|
Ozlu E, Karadag AS, Uzuncakmak TK, Ozkanli S, Erdem A, Akdeniz N. A psoralen and ultraviolet A-aggravated dermatosis: Grover's disease. Turk J Dermatol 2020;14:25-7
|How to cite this URL:|
Ozlu E, Karadag AS, Uzuncakmak TK, Ozkanli S, Erdem A, Akdeniz N. A psoralen and ultraviolet A-aggravated dermatosis: Grover's disease. Turk J Dermatol [serial online] 2020 [cited 2021 Apr 17];14:25-7. Available from: https://www.tjdonline.org/text.asp?2020/14/1/25/279397
| Introduction|| |
Grover's disease (GD) is a pruritic, papular, or papulovesicular dermatosis which is histopathologically characterized by acantholysis and dyskeratosis. It often shows spontaneous regression within weeks or months, although it may sometimes have a course with relapses and remissions. The etiology and pathogenesis of this condition are still unclear; however, the disease has been associated with triggering factors, including high body temperature, sweating, acute ultraviolet (UV) exposure, drug use, and internal malignancies., Topical treatment involves corticosteroids, calcipotriol and retinoids, and systemic treatment involves the use of vitamin A, synthetic retinoids, corticosteroids, methotrexate, and photo (chemo) therapy. GD is one of the skin conditions, which is sometimes aggravated by the UV light exposure.
| Case Report|| |
A 76-year-old female patient presented at our clinic with itchy lesions located under both breasts and in the lumbar region. These lesions were present for 2 years with exacerbation occurring in the summer season. The dermatological examination revealed erythematous, red-brown, papulovesicular lesions under both breasts and in the lumbar region [Figure 1]a and b]. The patient's systemic examination and laboratory tests were unremarkable. Histopathological evaluation of the biopsy specimen taken from the lesion revealed hyperkeratosis, acanthosis, spongiosis, suprabasal acantholysis, superficial dermal edema, perivascular neutrophilic, and eosinophilic inflammatory cell infiltrate [Figure 2]. The direct immunofluorescence examination did not reveal any particular findings. With the existing findings, the patient was diagnosed with GD. Topical clobetasol propionate 0.05% and topical calcipotriol cream were initiated. In the 3rd month of this treatment, no remission was detected and topical pimecrolimus 1% was initiated, but she could not use this therapy because of irritation. We started oral methylprednisolone 0.5 mg/kg/day but no remission was detected after 2 months of therapy. Thereafter, oral acitretin 0.5 mg/kg/day therapy was initiated. However, no remission was detected with oral acitretin therapy after 3 months. Thereafter, psoralen and UVA (PUVA) phototherapy three times weekly was initiated. Oral 8-methoxalene was given 0.5 mg/kg, 2 h before PUVA treatment. The initial doses were applied 0.5 joule/cm2. The patient developed generalized erythema and had aggravation of lesions after five sessions of PUVA phototherapy; therefore, the treatment was discontinued [Figure 1]c and [Figure 1]d.
|Figure 1: Erythematous, red-brown papulovesicular lesions under both breasts (a) and lumbar region (b). Generalized erythema and had aggravation of lesions on the chest (c) and back (d)|
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|Figure 2: Hyperkeratosis, acanthosis, spongiosis, suprabasal acantholysis, superficial dermal edema, perivascular neutrophilic, and eosinophilic inflammatory cell infiltrate (H and E, ×40)|
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| Discussion|| |
GD is often a benign, self-limiting disease; however, it may sometimes occur as a resistant and difficult to control dermatosis. The etiology of the disease is unknown, although several factors have been proposed to be associated with the disease, including the UV exposure, exposure to extreme temperature, and sweating. The distribution of the skin lesions and seasonal variations highlight the importance of the UV exposure, although rare occurrence of this condition suggests that other structural and environmental factors may play a role in the disease pathogenesis. Malignancies are one of the major causes of the etiology in patients with atypical and severe disease course; it has been suggested that the underlying malignancy contributes to the development of the disease by modifying the immune responses. The development of GD following transplantation, chemotherapy, and radiotherapy and atypical and severe disease course may support this hypothesis. In addition, Paslin reported a case of GD triggered by varenicline which acts as a nicotine antagonist. The lesions in the present case occurred in the summer months; however, further investigations did not show any malignancy or immunosuppression, and there was no history of drug use which might induce the disease.
In clinical practice, GD is characterized by papulovascular lesions with recurrent erythema which rapidly turn into crusted and keratotic erosions. Itching is one of the main symptoms of the disease which leads to severe distress. In addition, several conditions presenting with generalized papular lesions may mimic GD. The disease has four histopathological patterns, including Darier disease-like, Hailey-Hailey disease-like, pemphigus vulgaris-like, and spongiotic type. The most commonly reported subtypes are Darier disease-like and pemphigus vulgaris-like.
For the treatment of GD, UV phototherapy is a cost-effective modality which is successfully used in the treatment of many conditions in the practice of dermatology. The UV exposure is among the prominent triggering factors in etiopathogenesis of GD; however, the reports interestingly suggest that phototherapy can be also effective in the treatment of GD. The exact mechanism of action of phototherapy in GD is unknown. The reports have suggested that bathing and oral PUVA, particularly, can be effective in refractory cases., Furthermore, moderate-dose UVA-1 therapy has been demonstrated to be successful in cases in whom PUVA is unable to be administered. Liu and Letada reported a dramatic improvement in disease symptoms in a resistant case of GD using red light 5-aminolevulinic acid-photodynamic therapy. In the present case, the lesions spread to the whole trunk following five sessions of PUVA phototherapy, and therefore, therapy was discontinued.
In conclusion, GD is a dermatosis triggered by UV exposure; phototherapy is included in the treatment options. However, aggravation was observed soon after the treatment in the present case. Therefore, while treating GD with PUVA phototherapy, we suggest that clinicians should be aware of the possibility of aggravating lesions.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2]