Turkish Journal of Dermatology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 14  |  Issue : 3  |  Page : 71--75

The effect of coenzyme Q10 on serum glutathione peroxidase levels and severity of acne vulgaris


Maria Leleury, Diah Adriani, Retno Indar Widayati, Kabulrachman, Asih Budiastuti, Muslimin 
 Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Correspondence Address:
Dr. Maria Leleury
Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang
Indonesia

Objective: The objective of the study was to study the effect of coenzyme Q10 (CoQ10) supplementation on serum glutathione peroxidase (GSH-Px) levels and the severity of acne vulgaris (AV). Methods: A double-blind randomized controlled trial was carried out on 36 patients with AV classified according to severity. These patients were randomly divided into two groups (treatment group = 18 patients treated with tretinoin 0.025% cream and once-daily supplementation with a CoQ10 100 mg tablet; placebo group = 18 patients treated with tretinoin 0.025% cream and a once-daily placebo tablet). Blood samples were taken from a vein and examined by enzyme-linked immunosorbent assay. The study period was 8 weeks. Response to treatment was determined based on serum GSH-Px level and AV severity. The study used a pre- and post-test design for the two groups. The data were processed with SPSS for Windows version 25. Results: Administration of CoQ10 to AV significantly improved the severity of AV after 8 weeks compared to a placebo (P = 0.008). Serum GSH-Px levels after treatment with CoQ10 increase higher in the study than control group, but the statistical test result showed not significant in the study group (P = 0.3) and also control group (P = 0.07). Conclusion: CoQ10 supplementation may increase serum GSH-Px levels and improve the severity of AV, but there was no relationship between serum GSH-Px levels and the severity of AV.


How to cite this article:
Leleury M, Adriani D, Widayati RI, Kabulrachman, Budiastuti A, Muslimin. The effect of coenzyme Q10 on serum glutathione peroxidase levels and severity of acne vulgaris.Turk J Dermatol 2020;14:71-75


How to cite this URL:
Leleury M, Adriani D, Widayati RI, Kabulrachman, Budiastuti A, Muslimin. The effect of coenzyme Q10 on serum glutathione peroxidase levels and severity of acne vulgaris. Turk J Dermatol [serial online] 2020 [cited 2020 Dec 5 ];14:71-75
Available from: https://www.tjdonline.org/article.asp?issn=1307-7635;year=2020;volume=14;issue=3;spage=71;epage=75;aulast=Leleury;type=0